[1]吴丹红 李 华 李 晨 蒋筠斐 钟 萍.Logistic回归和ROC曲线评价生物标志物组 对大动脉粥样硬化性脑梗死的诊断价值[J].三才期刊采编系统演示平台,2015,1期(04):207-210.[doi:10.3969/j.issn.1007-0478.2015.04.004]
 Wu Danhong,Li Hua,Li Chen,et al.The diagnostic value of a biomarker panel for large artery atherosclerotic stroke with Logistic regression and ROC curve[J].,2015,1期(04):207-210.[doi:10.3969/j.issn.1007-0478.2015.04.004]
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Logistic回归和ROC曲线评价生物标志物组 对大动脉粥样硬化性脑梗死的诊断价值
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《三才期刊采编系统演示平台》[ISSN:1008-0341/CN:37-1280/R]

卷:
第1期
期数:
2015年04期
页码:
207-210
栏目:
论著
出版日期:
2015-12-31

文章信息/Info

Title:
The diagnostic value of a biomarker panel for large artery atherosclerotic stroke with Logistic regression and ROC curve
文章编号:
1007-0478(2015)04-0207-04
作者:
吴丹红 李 华 李 晨 蒋筠斐 钟 萍
201999 上海交通大学医学院附属第三人民医院神经内科(吴丹红 李 华 李 晨);
上海交通大学医学院附属第三人民医院检验科(蒋筠斐);
上海中医药大学附属上海市中西医结合医院脑病科[钟 萍(通信作者)]
Author(s):
Wu DanhongLi HuaLi Chenet al.
Department of Neurology,Shanghai Third People's Hospital, School of medicine, Shanghai Jiao Tong University,Shanghai 201999
关键词:
大动脉粥样硬化性脑梗死 脂蛋白相关磷脂酶A2 髓过氧化物酶 金属基质蛋白酶-9 脑钠肽
Keywords:
Large artery atherosclerotic stroke Lipoprotein-associated Phospholipase A2 Myeloperoxidase Matrix Metalloproteinase-9 Brain natriuretic peptide
分类号:
R743
DOI:
10.3969/j.issn.1007-0478.2015.04.004
文献标志码:
A
摘要:
目的 评估生物标志物组对大动脉粥样硬化性脑梗死的诊断价值。方法 88例大动脉粥样硬化性脑梗死患者和88例对照者入选本研究,分别检验脂蛋白相关磷脂酶A2(Lp-PLA2)、髓过氧化物酶(MPO)、金属基质蛋白酶-9(MMP-9)、超敏C反应蛋白(Hs-CRP)、纤维蛋白原(FIB)、脑钠肽(BNP),应用Logistic回归和ROC曲线分析生物标志物组对大动脉粥样硬化性脑梗死的诊断价值。结果 Logistic回归显示Lp-PLA2、MPO 、MMP9、BNP与诊断大动脉粥样硬化性脑梗死呈正相关(P<0.05),多变量模型ROC曲线下面积达到0.901。结论 生物标志物组(Lp-PLA2、MPO 、MMP9、BNP)对大动脉粥样硬化性脑梗死急性期的诊断提供了重要的价值。
Abstract:
ObjectiveThe diagnosis of acute ischemic stroke is limited by the lack of a widely available, rapid, and sensitive diagnostic test. The purpose of the current study was to observe blood biomarkers levels of patients with acute large artery atherosclerotic stroke, and assess whether a test using a panel of biomarkers might provide useful diagnostic information in the early evaluation of stoke.Methods 88 patients with acute large artery atherosclerotic stroke and 88 patients without acute ischemic stroke were enrolled. Blood samples were assayed for lipoprotein-associated Phospholipase A2(Lp-PLA2), myeloperoxidase(MPO), matrix Metalloproteinase-9(MMP-9), hypersensitive C-reactive protein, fibrinogen(Hs-CRP),and brain natriuretic peptide(BNP).The logistic regression and ROC curve were used to evaluate the diagnostic value of a biomarker panel for large artery atherosclerotic stroke.Results The logistic regression model demonstrated that a diagnostic test incorporating the value of Lp-PLA2, MPO, MMP9 and BNP into a composite score was sensitive for large artery atherosclerotic stroke. The area under the ROC curve was 0.901.Conclusions these results suggest that a biomarker panel(Lp-PLA2、MPO 、MMP9、BNP)may add important diagnostic information in the early evaluation of large artery atherosclerotic stroke.

参考文献/References:

1 Ballantyne CM, Hoogeveen RC, Bang H. Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the atherosclerosis risk in communities(ARIC)study. Arch Intern Med,2005,165(21):2479-2484.
2 Elkind MS, Leon V, Moon YP. High-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2 stability before and afterstroke and myocardial infarction. Stroke,2009,40(10):3233-3237.
3 Knauer C, Knauer K, Müller S. A biochemical marker panel in MRI-proven hyperacute ischemic stroke-a prospective study. BMC Neurol,2012,8:12-14.
4 中华医学会神经病学分会脑血管病学组 急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010.中华神经科杂志,2010,43(2)146-152.
5 Adams HP Jr, Bendixen BH, Kappelle LJ, et al. the TOAST investigators. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. Stroke,1993,24(1):35-41.
6 Oei HH, vander Meer IM, Hofinan A, et al. Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke:the Rotterdam stidy. Circulation, 2005, 111(5): 570-575.
7 钟 萍,吴丹红,吴计划,等.血清脂蛋白相关磷脂酶A2和超敏C-反应蛋白水平与大动脉粥样硬化性脑梗死关系的临床研究. 中华临床医师杂志,2012,6(4):924-927.
8 HoyA, Leininger-Muller B, Poirier O,et al. Myeloperoxidase polymorphisms in brain infarction. Association with infarct size and functional outcome. Atherosclerosis,2003,167(2):223-230.
9 Palm F1, Lahdentausta L, Sorsa T. Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study. Innate Immun. 2013,20(5):511-518.
10 Montaner J, Rovira A, Molina CA, et al. Plasmatic level of neuroinflammatory markers predict the extent of diffusion-weighted image lesions in hyperacute stroke. J Cereb Blood Flow Metab,2003,23(12):1403-1407.
11 Romanic AM, White RF, Arleth AJ, et al. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-
9 reduces infarct size. Stroke,1998,29(5):1020-1030.
12 Pola R. Inflammatory markers for ischaemic stroke. Thromb Haemost,2009, 101(5):800-801.
13 Di Napoli M, Schwaninger M, Cappelli R, et al. Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members. Stroke, 2005, 36(6):1316-1329.
14 Rost NS, Biffi A, Cloonan L, et al. Brain natriuretic peptide predicts functional outcome in ischemic stroke. Stroke, 2012, 43(2):441-445.
15 Woodward M, Lowe GD, Campbell DJ, et al. Associations of inflammatory and hemostatic variables with the risk of recurrent stroke. Stroke,2005,36(10):2143-2147.
16 Del Zoppo GJ, Levy DE, Wasiewski WW, et al. Hyperfibrinogenemia and functional outcome from acute ischemic stroke. Stroke, 2009, 40(5), 1687-1691.
17 Daniel TL, Scott EK, Jeffrey S, et al. Clinical usefulness of biomarker-based diagnostic test for acute stroke. Stroke, 2009,40(1):77-85.

备注/Memo

备注/Memo:
2015-02-12收稿
基金项目:上海市卫计委科研课题(项目编号为201440332和2012-460);
上海市科委引导项目(项目编号为14411972000)
更新日期/Last Update: 2015-08-30