[1]赵云清 罗建华 周其志 汪长英.阿司匹林抵抗对大动脉粥样硬化性 脑梗死复发的影响[J].三才期刊采编系统演示平台,2015,1期(04):219-221.[doi:10.3969/j.issn.1007-0478.2015.04.007]
 Zhao Yunqing,Luo Jianhua,Zhou Qizhi,et al.The influence of aspirin resistance on cerebral infarction recurrence with large artery atherosclerosis[J].,2015,1期(04):219-221.[doi:10.3969/j.issn.1007-0478.2015.04.007]
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阿司匹林抵抗对大动脉粥样硬化性 脑梗死复发的影响
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《三才期刊采编系统演示平台》[ISSN:1008-0341/CN:37-1280/R]

卷:
第1期
期数:
2015年04期
页码:
219-221
栏目:
论著
出版日期:
2015-12-31

文章信息/Info

Title:
The influence of aspirin resistance on cerebral infarction recurrence with large artery atherosclerosis
文章编号:
1007-0478(2015)04-0219-04
作者:
赵云清 罗建华 周其志 汪长英
529500 广东省阳东县人民医院脑科中心(赵云清 周其志 汪长英);
广州医科大学附属第三医院神经内科[罗建华(通信作者)]
Author(s):
Zhao YunqingLuo JianhuaZhou Qizhiet al.
Department of Neurology,Yangdong People's Hospital of Guangdong Province, Yangjiang 529500
关键词:
阿司匹林抵抗 动脉粥样硬化 脑梗死 血小板聚集率
Keywords:
Aspirin resistance Atherosclerosis Cerebral infarction Platelet aggregation rate
分类号:
R743
DOI:
10.3969/j.issn.1007-0478.2015.04.007
文献标志码:
A
摘要:
目的 观察阿司匹林抵抗(aspirin resistance,AR)对大动脉粥样硬化性脑梗死(large artery atherosclerosis cerebral infarction,LAACI)复发的影响。方法 选择阳东县人民医院首次发生LAACI患者269例,入院后即服用阿司匹林200mg,在7~10d后利用比浊法检测血小板聚集率,分为AR组40例,阿司匹林敏感组(aspirin sensitivity,AS)229例,进行随访6~12个月; 根据脑梗塞复发的情况分为大动脉粥样硬化复发(large artery atherosclerosis recurrence,LAAR)组38例和大动脉粥样硬化无复发(not large artery atherosclerosis recurrence,NLAAR)组231例,观察AR患者的危险因素,同时观察LAAR与AR之间的关系。结果 单因素分析中AR组的LAAR显著高于AS组(34.2% vs 11.7%,P=0.000),跟NLAAR组比较LAAR组患糖尿病、AR、年龄较大的比例均明显升高(P<0.05或0.01); 多因素分析中LAAR与AR明显相关(OR=4.692,95% CI=1.052~15.675,P=0.005)。结论 AR是LAAR的独立危险因素,能够增加LAAR的风险。
Abstract:
ObjectiveTo observe the influence of aspirin resistance on cerebral infarction recurrence with large artery atherosclerosis and the long-term curative effect of aspirin.Methods We collected 269 patients with ischemic stroke during November 2012 to November 2013 in Department of Neurology of yang-dong People's hospital, all patients took aspirin 200 mg/d,and then were divided into AR group and aspirin sensitivity(AS)group according to use Turbidimetry to measure the platelet aggregation rate after taking aspirin 7~10 d. Depending on the recurrence of cerebral infarction, the patients were divided into the group of large artery atherosclerosis recurrence(LAAR)group(229 cases)and not large artery atherosclerosis recurrence(NLAAR)group(231 cases)after following up 6~12 months, and observed the risk factors of patients with AR and the relationship between LAAR and AR.Results In single factor analysis, LAAR in AR group was significantly higher than the AS group(vs 11.7% 34.2%, P=0.000). LAAR in patients in LAAR with diabetes, AR, older were significant different(P<0.05 or 0.01), compared with NLAAR group.In multiple factors analysis, LAAR was significantly related with AR(OR=4.692, 95% CI=1.052~15.675, P=0.005).Conclusions AR is independent risk factors of LAAR, and can increase the risk of LAAR.

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备注/Memo

备注/Memo:
2015-01-07收稿
更新日期/Last Update: 2015-08-30